Approved for Philadelphia chromosome-positive chronic myeloid leukemia (Ph CML) in chronic, accelerated, and blast phases; Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph ALL); gastrointestinal stromal tumors (GIST) — unresectable/metastatic and adjuvant after resection; and several rarer conditions including myelodysplastic/myeloproliferative diseases and aggressive systemic mastocytosis.